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Vinflunine: Discovery and Synthesis of a Novel Microtubule Inhibitor

โœ Scribed by Jacques Fahy; Paul Hellier; Fabienne Breillout; Christian Bailly


Book ID
114474142
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
301 KB
Volume
35
Category
Article
ISSN
0093-7754

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โœ Andreas Speicher; Judith Holz ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 431 KB

Recently, remarkable microtubule inhibitor and anti-tumor activities of the bisbibenzyl marchantin Cisolated from liverworts like Marchantia polymorpha since 1983-were found. In this Letter we describe the first and efficient total synthesis of this subtype of bisbibenzylic compounds with two biaryl