Synthesis of marchantin C, a novel microtubule inhibitor from liverworts

✍ Scribed by Andreas Speicher; Judith Holz

• Book ID: 104097692
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 431 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.03.125

✦ Synopsis

Recently, remarkable microtubule inhibitor and anti-tumor activities of the bisbibenzyl marchantin Cisolated from liverworts like Marchantia polymorpha since 1983-were found. In this Letter we describe the first and efficient total synthesis of this subtype of bisbibenzylic compounds with two biarylether connections. The structure was confirmed by the spectroscopic data which were analyzed carefully to exclude any errors in arene connection and substitution pattern.