Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells
✍ Scribed by Pedro Casado; Pedro Zuazua-Villar; Eva del Valle; Carlos Martínez-Campa; Pedro S. Lazo; Sofía Ramos
- Book ID
- 116334231
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 669 KB
- Volume
- 247
- Category
- Article
- ISSN
- 0304-3835
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Since the small heat shock protein hsp27 enhances both growth and drug resistance in breast cancer cells, and is a bad prognostic factor in certain subsets of breast cancer patients, we have characterized the transcriptional regulation of hsp27, with the long-term goal of targeting its expression cl
## Abstract Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extr