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Vinca Alkaloids XXXII. Microbiological conversions of vindoline, a major alkaloid from vinca rosea L

✍ Scribed by N. Neuss; D. S. Fukuda; G. E. Mallett; D. R. Brannon; L. L. Huckstep

Publisher
John Wiley and Sons
Year
1973
Tongue
German
Weight
462 KB
Volume
56
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Vindoline, a major alkaloid from Vinca rosea ~L~ was subjected to microbiological conversion using Streptomyces cultures.

Several new metabolites were isolated and their structures elucidated.

πŸ“œ SIMILAR VOLUMES

Vinca alkaloids XXXIV. Preparation of de
Vinca alkaloids XXXIV. Preparation of des-Na-methyl-vindoline by microbiological conversion of vindoline, a major alkaloid from Vinca roseaL
✍ Norbert Neuss; D. S. Fukuda; D. R. Brannon; L. L. Huckstep πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 German βš– 120 KB

## Abstract The conversion of vindoline (II) using __S. albogriseolus__ led to the isolation of several compounds including des‐N~a~‐methyl vindoline (III) in 8–10% yield.

Vinca Alkaloids XXXIII [1]. Microbiologi
Vinca Alkaloids XXXIII [1]. Microbiological Conversions of Vincaleukoblastine (VLB, Vinblastine), an Antitumor Alkaloid from Vinca rosea. LINN
✍ N. Neuss; G. E. Mallett; D. R. Brannon; J. A. Mabe; H. R. Horton; L. L. Huckstep πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 German βš– 253 KB

## Abstract The conversion of VLB using different __Streptomycetes__ led to the isolation of VLB‐ether (**3**) and Hydroxy VLB (**6**). The structural assignments have been made by NMR. and high resolution mass spectral data.