✦ LIBER ✦

Vimentin expression in human squamous carcinoma cells: Relationship with phenotypic changes and cadherin-based cell adhesion

✍ Scribed by Shahidul Islam; Jae-Beom Kim; Jill Trendel; Margaret J. Wheelock; Keith R. Johnson

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 456 KB
Volume: 78
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(20000701)78:1<141::aid-jcb13>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

Phenotypic changes resembling an epithelial-to-mesenchymal transition often occur as epithelial cells become tumorigenic. Two proteins that have been implicated in this process are vimentin and N-cadherin. In this study, we sought to establish a link between expression of vimentin and N-cadherin as oral squamous epithelial cells undergo a morphologic change resembling an epithelial-to-mesenchymal transition. We found that N-cadherin and vimentin did not influence the expression of one another.

📜 SIMILAR VOLUMES

Distinct P-cadherin expression in cultur

Distinct P-cadherin expression in cultured normal human keratinocytes and squamous cell carcinoma cell lines

✍ Wakita, Hisashi; Shirahama, Shigeho; Furukawa, Fukumi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB 👁 2 views

Spatially regulated expression of E (epithelial)-and P (placental)-cadherins is crucial for maintaining normal epidermal architecture. In cutaneous squamous cell carcinomas (SCCs), aberrant P-cadherin expression is often observed in ''squamoid'' cancer cells, whereas E-cadherin expression in cancer

Plakoglobin induces desmosome formation

Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin

✍ Parker, Henry R. ;Li, Zhi ;Sheinin, Hannah ;Lauzon, Gille ;Pasdar, Manijeh 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

Pg is a homologue of beta-catenin and Armadillo, the product of the Drosophila segment polarity gene and has been shown to have both adhesive and signaling functions. It interacts with both classic and desmosomal cadherins. Pg interaction with the desmosomal cadherins is essential for desmosome asse

Co-expression of tenascin-C and vimentin

Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins

✍ N. Dandachi; C. Hauser-Kronberger; E. Moré; B. Wiesener; G. W. Hacker; O. Dietze 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB 👁 2 views

Overexpression of epidermal growth facto

Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion

✍ Pornchai O-Charoenrat; Peter Rhys-Evans; Helmout Modjtahedi; William Court; Gary 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 277 KB 👁 2 views

Numerous reports have shown an association between overexpression of the epidermal growth factor receptor (EGFR), and poor prognosis in head and neck squamous cell carcinomas (HNSCC), however, the underlying mechanisms are still unclear. In the present study, we set out to determine whether EGFR exp