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VIMENTIN EXPRESSION IN CERVICAL CARCINOMAS: ASSOCIATION WITH INVASIVE AND MIGRATORY POTENTIAL

✍ Scribed by GILLES, CHRISTINE; POLETTE, MYRIAM; PIETTE, JACQUES; DELVIGNE, ANNE-CATHERINE; THOMPSON, ERIK W.; FOIDART, JEAN-MICHEL; BIREMBAUT, PHILIPPE

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 774 KB
Volume: 180
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199610)180:2<175::aid-path630>3.0.co;2-g

No coin nor oath required. For personal study only.

✦ Synopsis

Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but evidence is accumulating in the literature which suggests that the aberrant expression of vimentin in epithelial cancer cells might be related to local invasiveness and metastatic potential. Vimentin expression has previously been associated with invasive properties in an in viiro model consisting of a set of HPV-33-transformed cervical keratinocyte cell lines.'J In the present study, in order to emphasize those in vitvo findings, the expression of vimentin has been investigated in cervical neoplasms of different grades, using immunohistochemistry. A clear association is reported between vimentin expression and metastatic progression, since vimentin was detected in all invasive carcinomas and lymph node metastases, but not in CIN 111 lesions. These in vivo results are compared with present and previous data obtained in vitvo on cervical keratinocyte cell lines, where vimentin expression also correlated with in vitro invasiveness.

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