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Vibratilicin: a Novel Compound from the Basidiomycete Cortinarius vibratilis

✍ Scribed by Fei Wang; Jian-Wen Tan; Ji-Kai Liu

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
83 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A novel N‐containing compound, vibratilicin (=3‐[3‐(dimethylamino)‐4‐(hydroxyamino)‐4‐oxobutoxy]‐2‐(palmitoyloxy)propyl (9__E__,12__E__)‐octadeca‐9,12‐dienoate; 1), was isolated from the fruiting bodies of the basidiomycete Cortinarius vibratilis Fr. Compound 1 is a representative of the rare natural products containing hydroxamic acid moieties, and can be viewed as a derivative of neoengleromycin (2). Also isolated from the same fungus were five known compounds: ergosta‐5,7,22‐trien‐3__β__‐ol, 5__α__,8__α__‐epidioxyergosta‐6,22‐dien‐3__β__‐ol, p‐anisic acid, N‐(2‐hydroxyhexadecanoyl)‐4‐sphingenine, and (4__E__,8__E__)‐2‐N‐(2′‐hydroxypalmitoyl)‐1‐O‐(β‐D‐glucopyranosyl)‐9‐methyl‐4,8‐sphingadienine. Their structures were determined mainly spectroscopically, including 2D‐NMR techniques (HMBC, HMQC, ^1^H,^1^H‐COSY).

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## Abstract Mitissimolone, a new regular sesquiterpene possessing a novel carbon skeleton, was isolated from the EtOH extract of fruiting bodies of __Lactarius mitissimus.__ Its structure was determined by extensive spectroscopic analyses including 1D‐ and 2D‐NMR spectra. Mitissimolone inhibited mo