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Viagra® (sildenafil citrate) and ophthalmology

✍ Scribed by Alan M Laties; Eberhart Zrenner


Book ID
114373123
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
683 KB
Volume
21
Category
Article
ISSN
1350-9462

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Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a ¼ 26.98 A ˚; b ¼ 11.95 A ˚; c ¼ 16.68 A ˚; b ¼

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The interaction of Ca(2+)-ions with sildenafil citrate (Viagra) leads to the precipitation of a new polymorph variety of sildenafil base. Under the same conditions, Mg(2+), Zn(2+), and Cd(2+) ions form structurally related crystalline complexes of the composition Me(2+)C(28)H(34)N(6)O(11)S. Lattice