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Physicochemical properties of sildenafil citrate (viagra) and sildenafil base

✍ Scribed by Petr Melnikov; Pedro P. Corbi; Alexandre Cuin; Mauricio Cavicchioli; Wellington R. Guimarães

Book ID
102396991
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
74 KB
Volume
92
Category
Article
ISSN
0022-3549

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✦ Synopsis

Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a ¼ 26.98 A ˚; b ¼ 11.95 A ˚; c ¼ 16.68 A ˚; b ¼ 106.978. [II]: a ¼ 8.66 A ˚; b ¼ 34.27 A ˚; c ¼ 8.93 A ˚; b ¼ 96.638. Both compounds decompose at 189.48C [I] and 251.98C [II]. Densities and refractive indices are given.

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The interaction of Ca(2+)-ions with sildenafil citrate (Viagra) leads to the precipitation of a new polymorph variety of sildenafil base. Under the same conditions, Mg(2+), Zn(2+), and Cd(2+) ions form structurally related crystalline complexes of the composition Me(2+)C(28)H(34)N(6)O(11)S. Lattice