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VH4.21 Expression in the Normal Human B-Cell Repertoire

✍ Scribed by DAVID F. FRIEDMAN; PIOTR KRAJ; LESLIE E. SILBERSTEIN


Book ID
119872578
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
590 KB
Volume
764
Category
Article
ISSN
0890-6564

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## Abstract We have previously demonstrated that at birth most productive (P) V~H~12 rearrangements in B10.H‐2^a^H‐4^b^p/Wts (2^a^4^b^) mice encode a ten‐amino acid CDR3, and that a significant fraction of the expected repertoire is absent. We have now examined the adult V~H~12 CDR3 repertoire invo