𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Vessel size imaging in humans

✍ Scribed by V. G. Kiselev; R. Strecker; S. Ziyeh; O. Speck; J. Hennig

Book ID
102955001
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
640 KB
Volume
53
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The relation of contrast‐enhanced transverse relaxation rates R~2~* and R~2~ provides in vivo mapping of the mean caliber of cerebral vessels. This technique is referred to as vessel size imaging (VSI). Here a quantitative assessment of the vessel caliber in brain tumor patients is presented. The obtained mean vessel size shows sensitivity to the tumor type. A theoretical analysis is given to elucidate the morphological information content of VSI in the context of vessel architecture. The simplification of the theory underlying the data processing results in a systematic overestimation of the vessel caliber. An increase in the magnetic susceptibility of the contrast agent allows for quantitatively more accurate measurements. Quantitative VSI must include measurements of the regional diffusion coefficient and absolute determination of the regional cerebral blood volume. Magn Reson Med 53:553–563, 2005. Β© 2005 Wiley‐Liss, Inc.

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