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Vernodalidimers A and B, novel orthoester elemanolide dimers from seeds of Vernonia anthelmintica

โœ Scribed by Yongqiang Liu; Alfarius E. Nugroho; Yusuke Hirasawa; Asami Nakata; Toshio Kaneda; Nahoko Uchiyama; Yukihiro Goda; Osamu Shirota; Hiroshi Morita; Haji Akber Aisa

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
384 KB
Volume
51
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Two novel elemanolide dimers, vernodalidimers A (1) and B (2), possessing a rare tricyclic ortho ester moiety, were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by 1D and 2D NMR data and CD spectra. Vernodalidimers A (1) and B (2) exhibited potent cell growth inhibitory activity against HL-60 cells (IC 50 0.72 and 0.47 lM, respectively).

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## Smg : Carapolide A, a novel hexanortriterpenoid, and carapolides B and C, novel tetranortriterpenoids have been isolated from the seeds of Varapa procera and have been assigned structures ( 2)) (10) and (11) respectively on the basis of chemical and spectroscopic evidente.