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Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms

✍ Scribed by Lisa L. von Moltke; Su Xiang Duan; David J. Greenblatt; Steven M. Fogelman; Jürgen Schmider; Jerold S. Harmatz; Richard I. Shader

Book ID
118510943
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
301 KB
Volume
41
Category
Article
ISSN
0006-3223

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## Abstract The cytochrome P450 enzyme cytochrome P450 3A4 (CYP3A4) controls the metabolism of about 60% of all drugs, and its inhibition may dramatically affect drug safety. Modulation of cytochrome P450 activity has been observed by constituents of fruit extracts including several flavonoids. The