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Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans

✍ Scribed by Tashinga E. Bapiro; Jane Sayi; Julia A. Hasler; Mary Jande; Gerald Rimoy; Amos Masselle; Collen M. Masimirembwa


Publisher
Springer
Year
2005
Tongue
English
Weight
132 KB
Volume
61
Category
Article
ISSN
0031-6970

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to