VEGF and the quest for tumour angiogenesis factors
β Scribed by Ferrara, Napoleone
- Book ID
- 109949059
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 196 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrc909
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Considerable evidence is gathering for the involvement of vascular endothelial growth factor (VEGF) in the vascularization and growth of primary tumours as well as in the formation of metastases. The expression of VEGF depends on activated oncogenes and inactivated tumour suppressor genes as well as
## Abstract Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex Gβ100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth o
## Abstract The formation of new microvasculature by capillary sprouting, or angiogenesis, is a prerequisite for solid tumor growth. The genetic alterations required to activate the angiogenic program in tumor angiogenesis are still only vaguely known, but dominantly acting oncoproteins may have a