Vector and Helper Genome Rearrangements Occur During Production of Helper-Dependent Adenoviral Vectors
✍ Scribed by Ahn, Miwon; Gamble, Aisha; Witting, Scott R.; Magrisso, Jack; Surendran, Sneha; Obici, Silvana; Morral, Núria
- Book ID
- 120155806
- Publisher
- Mary Ann Liebert
- Year
- 2013
- Tongue
- English
- Weight
- 310 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1946-6536
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## Abstract Safety requirements for adenoviral gene therapy protocols have led to the development of the third generation of vectors commonly called helper‐dependent adenoviral vectors (HDVs). HDVs have demonstrated a high therapeutic potential; however, the poor efficiency and reliability of the a
## Abstract ## Background The helper‐dependent (HD) adenoviral (Ad) vector relies on a helper virus to provide viral proteins for vector amplification. HD‐Ad vectors can significantly increase therapeutic gene expression and improve safety. However, the yield of an HD‐Ad vector is generally lower