## Abstract For Abstract see ChemInform Abstract in Full Text.
Vasorelaxant activity of 2-fluoroalkyl-6-nitro-2H-1-benzopyran-4-carbothioamide and -carboxamide K+ channel openers
โ Scribed by Haruhiko Sato; Hiroshi Koga; Takenori Ishizawa; Toshihiko Makino; Naoki Taka; Tadakatsu Takahashi; Hiroyuki Nabata
- Book ID
- 108038785
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 198 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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๐ SIMILAR VOLUMES
## Abstract Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4โdioxoโ3,4โdihydrophthalazineโ2(1__H__)โcarboxamides or 1,4โdioxoโ3,4โdihydrophthalโazineโ2(1__H__)โcarbothioamides under mild conditions and generally with good
The title reactions furnished the pyran ring cleaved product (3) and the tetracyclic chromene (5), rather than the expected 4-cyclicamido-3hydroxy benzopyrans (l,R=CN and NO2, respectively, n=ll). Mechanisms proposed for these reactions require a strong electron withdrawing group at C(6) in the benz