Synthesis and biological activity evaluation of differently substituted 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides and -carbothioamides

✍ Scribed by M. C. Cardia; S. Distinto; E. Maccioni; L. Bonsignore; A. Delogu

• Book ID: 102341909
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2003
• Tongue: English
• Weight: 46 KB
• Volume: 40
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570400609

✦ Synopsis

Abstract

Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4‐dioxo‐3,4‐dihydrophthalazine‐2(1__H__)‐carboxamides or 1,4‐dioxo‐3,4‐dihydrophthal‐azine‐2(1__H__)‐carbothioamides under mild conditions and generally with good yields. These compounds have been tested in order to evaluate their anti‐microbial activity. Furthermore a new synthetic pathway to phtha‐lazino[2,3‐b]phthalazine‐5,7,12,14‐tetraone has been devised.