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Vasopeptidase inhibitors: a new class of dual zinc metallopeptidase inhibitors for cardiorenal therapeutics

โœ Scribed by Giuseppe Molinaro; Jean-Lucien Rouleau; Albert Adam


Book ID
117786507
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
254 KB
Volume
2
Category
Article
ISSN
1471-4892

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Four primary zinc-binding pharmacophores (thiols, carboxylates, phosphorus acids, and hydroxamates) have been utilized in generating inhibitors of zinc metalloproteases such as ACE, NEP, the MMPs, and ECE. Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, V