N-Formyl hydroxylamine containing dipept
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Jeffrey A. Robl; Ligaya M. Simpkins; Magdi M. Asaad
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Article
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2000
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Elsevier Science
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English
โ 169 KB
Four primary zinc-binding pharmacophores (thiols, carboxylates, phosphorus acids, and hydroxamates) have been utilized in generating inhibitors of zinc metalloproteases such as ACE, NEP, the MMPs, and ECE. Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, V