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Therapeutics: Opening the door to a new class of proteasome inhibitors

✍ Scribed by Flemming, Alexandra


Book ID
109948876
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
254 KB
Volume
12
Category
Article
ISSN
1474-1776

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✍ Frank Marguet; Jean-FranΓ§ois Cavalier; Robert Verger; GΓ©rard Buono πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 312 KB πŸ‘ 2 views

Phosphonate compounds mimic the first transition state from a C-4 chiral synthon, 3-buten-1,2-diol -and treated with n-pentylphosphonic dichloride and p-nitrophenol to occurring during enzymatic carboxyester hydrolysis of natural substrates by forming a covalent bond with the afford the correspondin