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Vascular smooth muscle cells metabolize endothelin-1 in the absence of a functional receptor

✍ Scribed by Chandrashekhar R. Gandhi


Book ID
116106329
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
765 KB
Volume
1269
Category
Article
ISSN
0167-4889

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Two important mediators of endothelium-dependent regulation of vascular smooth muscle tone and proliferation are nitric oxide (NO) and endothelin (ET-1). An imbalance between NO and ET-1 may contribute to the alterations in vascular tone characteristic of cardiovascular disease. The objective of thi