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Vascular fractal dimension and total vascular area in the study of oral cancer

✍ Scribed by Lampros P. Goutzanis; Nikolaos Papadogeorgakis; Petros M. Pavlopoulos; Vasilis Petsinis; Ioannis Plochoras; Efstathios Eleftheriadis; Aikaterini Pantelidaki; Efstratios Patsouris; Constantinos Alexandridis

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
810 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

Microvessel quantification has been studied extensively as a factor reflecting angiogenesis in various malignant tumors. The aim of our study was to evaluate the vascular fractal dimension and the immunohistochemically positive total vascular area in oral cavity carcinomas in order to assess their potential value as factors reflecting angiogenesis.

Methods

Histologic sections from 48 carcinomas and 17 nonmalignant mucosa specimens were evaluated by image analysis using fractal analysis software. Total vascular area was also quantified.

Results

Carcinomas presented higher mean values of vascular fractal dimension and total vascular area compared to normal mucosa. The difference for the vascular fractal dimension was statistically significant.

Conclusions

This study provides evidence that vascular fractal dimension could be used as a reliable factor reflecting angiogenesis in oral squamous cell carcinoma and that there are several statistically significant correlations among total vascular area, vascular fractal dimension, nuclear size, and clinicopathologic factors. Β© 2008 Wiley Periodicals, Inc. Head Neck, 2009

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