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Evaluation of oral thymoxamine in patients with peripheral vascular occlusion of the lower limbs

✍ Scribed by Margaret Thomas; H. Campbell; G. E. Heard

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
337 KB
Volume
60
Category
Article
ISSN
0007-1323

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✦ Synopsis

Abstract

To determine the effectiveness of oral thymoxamine (Opilon) as a cutaneous vasodilator in patients with peripheral vascular occlusion of the lower limb, double-blind trials of a placebo, of tolazoline in a dose of 50 mg., and of thymoxamine in single doses of 20, 40, 60, 80, and 100 mg. have been undertaken using skin temperature and skin blood-flow as measures of response. Thymoxamine produced no significant increases in skin temperature and blood-flow at any dose level, whereas in the same patients tolazoline produced highly significant increases.

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