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Vascular bed and vasoconstrictor-dependent selectivity of the calcium channel antagonist, PN 200-110

✍ Scribed by Anna Bijak; Andre Pasternac; Grant A. McPherson; John A. Bevan


Book ID
115880272
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
310 KB
Volume
132
Category
Article
ISSN
0014-2999

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PN 200-l 10 (Isrodipine). a calcium channel antagonist, was labelled with "C (I, 2 20.4 min) by a reaction between [" Cldiazomethane and the carboxyt precursor. The ["C]CH2Nz is prepared in two stages from ["CICH,: ["C]CH,~["C]CHCI,~["C]CHZN,. When a mixture of nitrogen (95%) and hydrogen (5%) is i