Varicella-Zoster Virus Gene Expression in Latently Infected Rat Dorsal Root Ganglia
โ Scribed by Peter G.E. Kennedy; Esther Grinfeld; Sebastien Bontems; Catherine Sadzot-Delvaux
- Book ID
- 112273797
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 439 KB
- Volume
- 289
- Category
- Article
- ISSN
- 0042-6822
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We describe here the first in vivo model of varicellazoster virus (VZV) latent infection in the adult rat peripheral nervous system. Infected Mew0 cells were injected subcutaneously along the spine of healthy adult rats. No clinical sign of infection was observed even 9 months after inoculation. Hum
Newborn rats were injected intraperitoneally with uninfected human cells or cell infected with 56,000 pfu of varicella-zoster virus (VZV). Five to 6 weeks later, trigeminal ganglia were harvested and tested for VZV DNA and RNA by PCR. VZV gene 21 and 40 DNA were detected in most infected animals. Ge
Varicella-zoster virus (VZV) becomes latent in the sensory ganglia after primary infection and VZV DNA has been found in human trigeminal, thoracic, and geniculate ganglia. In this study, human vestibular and spiral ganglia, which do not received innervation from the skin, were examined for VZV DNA