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Variations of the melanocortin-1 receptor and the glutathione-Stransferase T1 and M1 genes in cutaneous malignant melanoma

✍ Scribed by Rotraut Mössner; Nils Anders; Inke R. König; Ullrich Krüger; Diane Schmidt; Carola Berking; Andreas Ziegler; Jürgen Brockmöller; Rolf Kaiser; Matthias Volkenandt; Götz A. Westphal; Kristian Reich


Book ID
106078690
Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
402 KB
Volume
298
Category
Article
ISSN
0340-3696

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The melanocortin 1 receptor, a Gs proteincoupled receptor expressed in epidermal melanocytes, is a major determinant of skin pigmentation and phototype and an important contributor to melanoma risk. MC1R activation stimulates synthesis of black, strongly photoprotective eumelanin pigments. Several M