Variation in the proregion structure of heparin-binding EGF-like growth factor precursors
โ Scribed by Evgenij V Loukianov; Tanya Loukianova; Antoni Wiedlocha; Sjur Olsnes
- Book ID
- 117523051
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 153 KB
- Volume
- 212
- Category
- Article
- ISSN
- 0378-1119
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## Abstract Heparinโbinding EGFโlike growth factor (HBโEGF), which belongs to the EGFโfamily of growth factors, was isolated from the conditioned medium of macrophageโlike cells. To investigate the effect of __N__โ and __C__โterminal residues of the EGFโlike domain of HBโEGF in the binding affinity
Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family and is highly expressed in hepatoma tissues but not in normal liver. However, it is unknown when HB-EGF is induced during hepatocarcinogenesis and what are the mechanisms underlying its high expre