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High expression of heparin-binding EGF-like growth factor in rat hepatocarcinogenesis

✍ Scribed by Eiji Miyoshi; Shigeki Higashiyama; Takatoshi Nakagawa; Keiichiro Suzuki; Masayoshi Horimoto; Norio Hayashi; Hideyuki Fusamoto; Takenobu Kamada; Naoyuki Taniguchi

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
511 KB
Volume
68
Category
Article
ISSN
0020-7136

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✦ Synopsis

Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family and is highly expressed in hepatoma tissues but not in normal liver. However, it is unknown when HB-EGF is induced during hepatocarcinogenesis and what are the mechanisms underlying its high expression in hepatoma. To address this issue, the expression of HB-EGF was investigated during hepatocarcinogenesis in LEC (Long-Evans with a cinnamon-like coat color) rats, which spontaneously develop hepatitis and hepatoma. LEA (Long-Evans with an agouti coat color) rats were used as controls. Furthermore, the induction of HB-EGF mRNA by various agents was investigated in a rat hepatoma cell line and hepatocytes in primary culture. Expression of HB-EGF mRNA in the liver was very low at the stage of acute and chronic hepatitis and markedly increased at the stage of hepatoma in LEC rats. Non-involved tissues adjacent to hepatoma showed low expression of HB-EGF mRNA. Immunochemical studies revealed positive staining in hepatoma tissues. Induction of HB-EGF mRNA by several growth factors was observed in a hepatoma cell line but not in normal hepatocytes. Our results suggest that HB-EGF is associated with the early progression steps of hepatoma.

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