The presence of high affinity binding sites for 3H-imipramine (3H-IMI) in human platelets is by now well established. This recognition site is associated with the transporter for 5HT, and may be a biological marker in depression. Fluctuations of other putative biological markers of depression (i.e.
Variation in platelet [3H]imipramine binding during the menstrual cycle in healthy young women
β Scribed by Peter M. Ellis; C. Joy McIntosh; Russell R. Cooke
- Book ID
- 102267204
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 345 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0885-6222
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β¦ Synopsis
Platelet ['Hlimipramine binding, a putative biological marker for depression, varies considerably among healthy control subjects. This study examined whether changes associated with the menstrual cycle could account for part of this variability. No significant relationship was found between B,,, or Kd and the phase of the menstrual cycle, or symptoms associated with the premenstrual syndrome or progesterone or oestradiol levels. Other factors should be considered in exploring the variability of ['Hlimipramine binding in healthy subjects.
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