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Platelet3H-imipramine binding and steroid hormones serum concentrations during the menstrual cycle

โœ Scribed by Marie-France Poirier; Chawki Benkelfat; Anne-Marie Galzin; Salomon Z. Langer

Book ID
104716671
Publisher
Springer
Year
1986
Tongue
English
Weight
449 KB
Volume
88
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

The presence of high affinity binding sites for 3H-imipramine (3H-IMI) in human platelets is by now well established. This recognition site is associated with the transporter for 5HT, and may be a biological marker in depression. Fluctuations of other putative biological markers of depression (i.e. platelet MAO activity) have been demonstrated and shown to be correlated with variations in steroid hormones. Therefore, the KD and Bmax of 3H-IMI binding was determined in platelets of young women during the menstrual cycle. Our results indicate that within the limits of intraindividual variations, neither the KD or the Bmax of 3H-IMI binding in platelets is significantly modified during the menstrual cycle.

๐Ÿ“œ SIMILAR VOLUMES

Variation in platelet [3H]imipramine bin
Variation in platelet [3H]imipramine binding during the menstrual cycle in healthy young women
โœ Peter M. Ellis; C. Joy McIntosh; Russell R. Cooke ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 345 KB

Platelet ['Hlimipramine binding, a putative biological marker for depression, varies considerably among healthy control subjects. This study examined whether changes associated with the menstrual cycle could account for part of this variability. No significant relationship was found between B,,, or