Variants at the 9p21 locus and melanoma risk
✍ Scribed by Livia Maccioni, Panduranga Sivaramakrishna Rachakonda, Justo Lorenzo Bermejo…
- Book ID
- 120680081
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 800 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1471-2407
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The cyclin-dependent kinase-4 inhibitor gene CDKN2, localized at chromosome region 9 ~2 1 , has been shown to be a familial melanoma gene, though we found that mutations of it are rare in uncultured sporadic melanomas. To determine whether the region of allelic loss at 9p2 I frequently observed in s
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