Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11-p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and ot
Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma
✍ Scribed by M.C. Sini; A. Manca; A. Cossu; M. Budroni; G. Botti; P.A. Ascierto; F. Cremona; A. Muggiano; S. D’Atri; M. Casula; P. Baldinu; G. Palomba; A. Lissia; F. Tanda; G. Palmieri
- Book ID
- 108669796
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 539 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0007-0963
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We examined 82 cases of primary non-small cell lung cancer (NSCLC) for loss of heterozygosity (LOH) at the chromosome 9p21-24 region using 16 microsatellite markers. A total of 52 tumors (63%) displayed LOH, and 25 of these cases displayed LOH for all markers. Two cases had small hemizygous losses c