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Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibiting p53 activation

✍ Scribed by Liu, Lijuan; Chen, Xiaobei; Xie, Shuixiang; Zhang, Chuanjie; Qiu, Zhenpeng; Zhu, Fan


Book ID
118759115
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
859 KB
Volume
56
Category
Article
ISSN
0270-9139

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## Abstract Hepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in patients with HCC. Presently, we demonstrate that oxaliplatin triggers necrosis more than apoptosis in HepG2,