Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1

Growth arrest by troglitazone is mediate

Growth arrest by troglitazone is mediated by p27Kip1 accumulation, which results from dual inhibition of proteasome activity and Skp2 expression in human hepatocellular carcinoma cells

✍ Wataru Motomura; Nobuhiko Takahashi; Miho Nagamine; Mitsuko Sawamukai; Satoshi T 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 146 KB

## Abstract In our study, we examined whether human hepatocellular carcinoma (HCC) expresses peroxisome proliferator‐activated receptor γ (PPARγ) and the effects of PPAR γ activation by its selective ligands on cell growth and cell invasion in HCC cells. RT‐PCR and Western blot analysis revealed th