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Variance component models for X-linked QTLs

✍ Scribed by Kenneth Lange; Eric Sobel

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 99 KB
Volume: 30
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.20158

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✦ Synopsis

Abstract

This paper discusses the theory and implementation of a model for mapping X‐linked quantitative trait loci (QTL). As a result of X inactivation, a female's body is subdivided into a number of patches. In each patch one of her two X chromosomes is randomly switched off. This smooths the allelic contributions in a heterozygote and implies that females should show less trait variation than males for an X‐linked trait. The latest version of the genetic analysis program Mendel incorporates a simple variance component version of this model. An application to head circumference in autistic children illustrates Mendel in action. Genet. Epidemiol. 2006. © 2006 Wiley‐Liss, Inc.

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