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Deriving components of genetic variance for multilocus models

✍ Scribed by Hemant K. Tiwari; Robert C. Elston

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
50 KB
Volume
14
Category
Article
ISSN
0741-0395

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✦ Synopsis

Several authors have considered two-locus models as a basis for the inheritance of complex diseases. The purpose of this paper is to give a simple general formulation to derive the additive, dominant, and epistatic effects, and hence the corresponding variance components, for any multilocus model. These variance components should be useful for investigating the power of model-free linkage analysis to detect various modes of multilocus inheritance.

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