We present a novel method, IBDLD, for estimating the probability of identity by descent (IBD) for a pair of related individuals at a locus, given dense genotype data and a pedigree of arbitrary size and complexity. IBDLD overcomes the challenges of exact multipoint estimation of IBD in pedigrees of
Variance Calculations for Identity-by-Descent Estimation
β Scribed by Matthew B. McQueen; Deborah Blacker; Nan M. Laird
- Book ID
- 117854807
- Publisher
- American Society of Human Genetics
- Year
- 2006
- Tongue
- English
- Weight
- 652 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/503920
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In some clinical and research settings, it is often necessary to identify the true level of "identity by descent" (IBD) between two individuals. However, as the individuals become more distantly related, it is increasingly difficult to accurately calculate this value. Consequently, we have developed
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