✦ LIBER ✦

Variable low-mass filtering using an electrodynamic ion funnel

✍ Scribed by Jason S. Page; Aleksey V. Tolmachev; Keqi Tang; Richard D. Smith

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 628 KB
Volume: 40
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.900

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✦ Synopsis

Abstract

An adjustable low‐mass filter has been developed for an electrospray ionization (ESI) source to block ions associated with unwanted background species from entering the mass spectrometer. The low‐mass filter is made by using an adjustable potential energy barrier from the conductance‐limiting plate of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from exiting the ESI source. We show that this arrangement provides a linear voltage adjustment for low‐mass filtering from m/z 0 to 500. Mass filtering above m/z 500 is also performed; however, higher‐mass species are attenuated. The mass filter was tested with a liquid chromatography/mass spectrometry (LC/MS) analysis of a bovine serum albumin (BSA) tryptic digest and resulted in the ability to block low‐mass, background species, which accounted for 40–70% of the total ion current immediately behind the ESI source during peak elution and detection. Copyright © 2005 John Wiley & Sons, Ltd.

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