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Variability of the Nonstructural 5A Protein of Hepatitis C Virus Type 3a Isolates and Relation to Interferon Sensitivity

✍ Scribed by Castelain, Sandrine; Khorsi, Hafida; Roussel, Juliette; François, Catherine; Jaillon, Olivier; Capron, Dominique; Penin, François; Wychowski, Czeslaw; Meurs, Eliane; Duverlie, Gilles

Book ID
121845847
Publisher
University of Chicago Press
Year
2002
Tongue
English
Weight
842 KB
Volume
185
Category
Article
ISSN
0022-1899

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## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNA‐dependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire