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Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa

✍ Scribed by G Squadrito; F Leone; M Sartori; B Nalpas; P Berthelot; G Raimondo; S Pol; C Brechot

Book ID
119755770
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
304 KB
Volume
113
Category
Article
ISSN
0016-5085

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Amino acid (aa) mutations in the interferon-sensitivity determining region (ISDR) (aa position 237-276 of the nonstructural region 5A [NS5A] protein consisting of 447 amino acids) of hepatitis C virus (HCV) are related to increased interferon sensitivity and low viral load, but its mechanism has not