𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Variability of pharmacokinetic parameters of valproic acid and two of its metabolites

✍ Scribed by J. Darius; U. Tröger; F.P. Meyer

Book ID
119179445
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
136 KB
Volume
31
Category
Article
ISSN
1043-6618

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The Hepatotoxicity of Valproic Acid and
The Hepatotoxicity of Valproic Acid and Its Metabolites in Rats. II. Intermediary and Valproic Acid Metabolism
✍ G. Richard Granneman; Shyh-Ing Wang; James W. Kesterson; Joseph M. Machinist 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 685 KB

The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch

Pharmacokinetic analysis and anticonvuls
Pharmacokinetic analysis and anticonvulsant activity of two polyesteric prodrugs of valproic acid
✍ Salim Hadad; Tom B. Vree; Eppo Van Der Kleijn; Meir Bialer 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 464 KB 👁 2 views

## Abstract The pharmacokinetics of the following two polyesteric prodrugs of valproic acid (VPA) have been investigated: 1,4‐butanediol divaiproate (BDV) and glyceryl trivalproate (GTV). In addition, the anticonvulsant activity of these compounds has been evaluated and compared to that of VPA and

Pharmacokinetics of valproic acid and me
Pharmacokinetics of valproic acid and metabolites in mouse plasma and brain following constant-rate application of the drug and its unsaturated metabolite with an osmotic delivery system
✍ Heinz Nau; Rainer Zierer 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 603 KB

## Abstract Human therapeutic valproic acid (VPA) levels could be maintained in the mouse for a period of 1 week by constant rate application via subcutaneously implanted osmotic minipumps. Also, the concentrations of VPA metabolites observed in mouse plasma were similar to those seen in human plas