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Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding D-Ala-D-Ala

โœ Scribed by Ge, M.


Book ID
121008124
Publisher
American Association for the Advancement of Science
Year
1999
Tongue
English
Weight
366 KB
Volume
284
Category
Article
ISSN
0036-8075

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Binding of a dimeric derivative of vanco
โœ Jianghong Rao; Lin Yan; Joydeep Lahiri; George M Whitesides; Robert M Weis; H Sh ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 616 KB

## Background: The emergence of bacteria that are resistant to vancomycin (V), a glyeopeptide antibiotic, results from the replacement of the carboxy-terminal D-Ala-D-Ala of bacterial cell wall precursors by D-Ala-D-lactate. Recently, it has been demonstrated that covalent dimeric variants of V are