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Tight Binding of a Dimeric Derivative of Vancomycin with Dimeric l -Lys- d -Ala- d -Ala

✍ Scribed by Rao, Jianghong; Whitesides, George M.


Book ID
127204172
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
156 KB
Volume
119
Category
Article
ISSN
0002-7863

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Binding of a dimeric derivative of vanco
✍ Jianghong Rao; Lin Yan; Joydeep Lahiri; George M Whitesides; Robert M Weis; H Sh πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 616 KB

## Background: The emergence of bacteria that are resistant to vancomycin (V), a glyeopeptide antibiotic, results from the replacement of the carboxy-terminal D-Ala-D-Ala of bacterial cell wall precursors by D-Ala-D-lactate. Recently, it has been demonstrated that covalent dimeric variants of V are