Binding of a dimeric derivative of vanco
Binding of a dimeric derivative of vancomycin to l-Lys-d-Ala- d-lactate in solution and at a surface
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Jianghong Rao; Lin Yan; Joydeep Lahiri; George M Whitesides; Robert M Weis; H Sh
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Article
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1999
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Elsevier Science
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English
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## Background: The emergence of bacteria that are resistant to vancomycin (V), a glyeopeptide antibiotic, results from the replacement of the carboxy-terminal D-Ala-D-Ala of bacterial cell wall precursors by D-Ala-D-lactate. Recently, it has been demonstrated that covalent dimeric variants of V are