Vanadium-catalyzed oxidative aromatization of 2-cyclohexenones under molecular oxygen

✍ Scribed by Toshiyuki Moriuchi; Kotaro Kikushima; Tomomi Kajikawa; Toshikazu Hirao

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 378 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.10.070

✦ Synopsis

An efficient catalytic oxidative aromatization of 2-cyclohexenones was achieved by a combination of a commercially available inexpensive ligand-free vanadium catalyst, a bromide source, and an acid under atmospheric oxygen to afford the corresponding phenol derivatives. This catalytic oxidative aromatization proceeded even under air. Furthermore, a gram-scale reaction was performed successfully.