Endothelin-1 (ET-1) controls multiple aspects of kidney function. In this study we have analysed the effects of ET-1 on apical Na+/H + exchange activity in opossum kidney (OK) cells. ET-1 (at 10-1~ and 10-SM) activated Na+/H + exchange activity within 5 min of exposure. ET-1 (10 -8 M) prevented PTHi
Vanadate stimulates Na+H+ exchange activity in A431 cells
โ Scribed by Dan Cassel; Ying-Xin Zhuang; Luis Claser
- Book ID
- 115757955
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 389 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0006-291X
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Previous studies have documented the activation of Na+/H+ exchange in A431 cells by the addition of epidermal growth factor or serum (Rothenberg et al., 1983b). Here we show that exposure of A4 31 cells to medium of increased osmolarity also leads to activation of Na+/H+ exchange and to an increase
A previous report from this laboratory (Rothenberg et al., 1983a) demonstrated the presence of an Na+/H + exchanger in human epidermoid carcinoma A431 cells. We now characterize surfacederived membrane vesicles from this cell line which contain a functional Na+lH+ exchanger. The Na+/H+ exchanger in