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Value of pedigree/clinical data, immunohistochemistry and microsatellite instability analyses in reducing the cost of determining hMLH1 and hMSH2 gene mutations in patients with colorectal cancer

โœ Scribed by T. Debniak; G. Kurzawski; B. Gorski; J. Kladny; W. Domagala; J. Lubinski


Book ID
117666860
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
111 KB
Volume
36
Category
Article
ISSN
0959-8049

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Germ line mutations of hMSH2 and hMLH1 g
โœ M. Miyaki; M. Konishi; M. Muraoka; R. Kikuchi-Yanoshita; K. Tanaka; T. Iwama; T. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer ๐ŸŒ English โš– 848 KB

Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o