Validation of whole genome amplification for analysis of the p53 tumor suppressor gene in limited amounts of tumor samples
β Scribed by Johanna Hasmats; Henrik Green; Beata Werne Solnestam; Pawel Zajac; Mikael Huss; Cedric Orear; Pierre Validire; Magnus Bjursell; Joakim Lundeberg
- Book ID
- 116303793
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 455 KB
- Volume
- 425
- Category
- Article
- ISSN
- 0006-291X
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Human hepatocellular carcinomas from patients in Britain, an area of low prevalence of hepatocellular carcinoma and low dietary exposure to aflatoxin B,, were analyzed for mutations in the p53 tumorsuppressor gene. Abnormalities in the pS3 gene were detected in 2 of 19 hepatocellular carcinomas by p
## Detection of mutations and polymorphisms in the p53 tumor suppressor gene by single-strand conformation polymorphism analysis Deciphering the genetic mechanisms in cancer development requires analysis of a large number of tumors for consistent genetic alterations. Single-strand conformational p