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Validation of the 4B5 rabbit monoclonal antibody in determining Her2/neu status in breast cancer

✍ Scribed by van der Vegt, Bert; de Bock, Geertruida H; Bart, Joost; Zwartjes, Nick G; Wesseling, Jelle


Book ID
109887789
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
207 KB
Volume
22
Category
Article
ISSN
0893-3952

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HER-2lneu oncogene status and total cellular p I 8SHER-' content were simultaneously analyzed in 4 I 5 invasive breast-cancer specimens by differential PCR and ELISA respectively. Mathematical analysis of the data led us to establish a cut-off value of I .7 for the ratio between the intensity of the