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Validation of Real-Time Methylation-Specific PCR to Determine O6-Methylguanine-DNA Methyltransferase Gene Promoter Methylation in Glioma

✍ Scribed by Vlassenbroeck, Ilse; Califice, Stéphane; Diserens, Annie-Claire; Migliavacca, Eugenia; Straub, Josef; Di Stefano, Ivano; Moreau, Fabrice; Hamou, Marie-France; Renard, Isabelle; Delorenzi, Mauro

Book ID
123532388
Publisher
American Society for Investigative Pathology
Year
2008
Tongue
English
Weight
406 KB
Volume
10
Category
Article
ISSN
1525-1578

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O 6 -Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20-30% of human tumor lines is tightly linked to methylati